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Liver Detoxification Pathways

The liver is an essential organ. It plays a role in metabolism, digestion, energy storage, and hormone production. It is also the major detoxifying organ in the body. Detoxification in the liver is broken into two categories. They are known as Phase I and Phase II liver detoxification pathways. Phase I Liver Detoxification Pathway Phase I liver detoxification is the first line of defense against toxins. It consists of a group of enzymes known as the cytochrome P450 family. The enzymes help neutralize substances like alcohol and caffeine. They offer protection by converting these toxins into less harmful ones. The byproducts of Phase I liver detoxification can still pose a toxic threat to the body. If the toxins are allowed to build up and stay in the liver, they can damage DNA and proteins. It is the role of Phase II liver detoxification, to make sure that those toxins do not build up. Which provides final neutralization of the toxins so that they can be removed by the body. Phase ...